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A common cause of focal uptake in the liver on bone scintigraphy is the presence of metastatic deposits from lung carcinoma, breast carcinoma, adenocarcinoma of the gastrointestinal tract , and osteosarcoma.
The differential diagnosis of diffuse liver uptake includes residual radioactivity from a liver scintigram performed the previous day, or administration of radiopharmaceutica of lesser quality with excess Tc-99m colloid. Colloids can be caused by excess aluminum ions in the eluate, hydrolysis of stannous chloride to stannous hydroxide, or excessive hydrolyzed technetium in the preparation.
Metastatic colon carcinoma.
The bone scintigram (A) demonstrates patchy uptake of the radiotracer in the
liver, corresponding to multiple metastases seen on CT (B).
Metastatic disease
The bone scintigram (A) demonstrates patchy uptake in the liver corresponding
to multiple metastases seen on CT (B).
Metastases
The bone scintigram (A) demonstrates patchy uptake in the liver corresponding
to multiple metastases seen on CT (B).
Metastatic osteosarcoma.
The bone scintigram (A) shows four areas of intense radionuclide uptake in
the liverand in the left supraclavicular lymph nodes. The CT scan of the liver
(B) demonstrates at least two ossified liver metastases.
Aluminum in the generator
The bone scintigram shows diffusely increased hepatic radionuclide activity as a result of excessive aluminum ion in the eluate.